Mapk3 Gene Summary [Rat]
Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonate metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk3 |
| Official Name | mitogen activated protein kinase 3 [Source:RGD Symbol;Acc:3046] |
| Ensembl ID | ENSRNOG00000053583 |
| Bio databases IDs | |
| Aliases | mitogen activated protein kinase 3 |
| Synonyms | ERK-1, ERT2, Esrk1, HS44KDAP, HUMKER1A, MAPK1, Mapkapk3, Mapk p44, mitogen-activated protein kinase 3, MNK1, MTAP2K, p44, p44 Erk, P44ERK1, P44MAPK, PRKM3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mapk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation lip domain
- protein serine/threonine kinase
- protein kinase
- ATP-binding domain
- ATP binding
- phosphotyrosine binding
- transcription factor binding
- dual-specificity motif
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- MAP kinase
- alcohol group acceptor phosphotransferase
- phosphatase binding
Pathways
Biological processes and signaling networks where the Mapk3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Agrin Interactions at Neuromuscular Junction
- Amyloid Processing
- Aryl Hydrocarbon Receptor Signaling
- Cancer Drug Resistance By Drug Efflux
- Chemokine Signaling
- CNTF Signaling
- CXCR4 Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Melatonin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Semaphorin Signaling in Neurons
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- epithelial cancer
- tumorigenesis
- obesity
- hyperplasia
- airway hyperresponsiveness
- gastric cancer
- bleeding
- leiomyoma
- uterine leiomyoma
role in cell
- apoptosis
- number
- proliferation
- production in
- binding in
- invasion by
- morphology
- quantity
- expression in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- microtubule cytoskeleton
- cytoskeleton
- cilia
- perinuclear region
- microvesicles
- focal adhesions
- Nucleus
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- Mitochondria
- cytosol
- endoplasmic reticulum lumen
- caveolae
- nucleoplasm
- nuclear envelope
- early endosomes
- late endosomes
- pseudopodia
- meiotic spindles
- kinetochores
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mapk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to epidermal growth factor stimulus
- trachea formation
- positive regulation of cyclase activity
- cellular response to amino acid starvation
- signal transduction in response to DNA damage
- face development
- regulation of Golgi inheritance
- BMP signaling pathway
- caveolin-mediated endocytosis
- apoptotic process
- intracellular signal transduction
- stress-activated MAPK cascade
- insulin-like growth factor receptor signaling pathway
- positive regulation of telomerase activity
- regulation of cytoskeleton organization
- regulation of stress-activated MAPK cascade
- sensory perception of pain
- lipopolysaccharide-mediated signaling pathway
- regulation of synaptic transmission
- cellular response to reactive oxygen species
- cartilage development
- regulation of early endosome to late endosome transport
- Schwann cell development
- insulin receptor signaling pathway
- Bergmann glial cell differentiation
- ERBB2-ERBB3 signaling pathway
- outer ear morphogenesis
- myelination
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- lung morphogenesis
- thymus development
- MAPK cascade
- response to exogenous dsRNA
- cellular response to cadmium ion
- positive regulation of macrophage chemotaxis
- cellular response to tumor necrosis factor
- phosphorylation
- regulation of cellular pH
- transcription, DNA-dependent
- peptidyl-tyrosine autophosphorylation
- cardiac neural crest cell development involved in heart development
- ERK1 and ERK2 cascade
- cellular response to mechanical stimulus
- thyroid gland development
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of telomere maintenance via telomerase
- interleukin-1-mediated signaling pathway
- regulation of ossification
Cellular Component
Where in the cell the gene product is active
- late endosome
- Golgi apparatus
- plasma membrane
- nucleoplasm
- nuclear envelope
- nucleus
- endoplasmic reticulum lumen
- early endosome
- caveola
- cytoskeleton
- focal adhesion
- cytoplasm
- mitochondrion
- cytosol
- pseudopodium
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- phosphotyrosine binding
- ATP binding
- identical protein binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity