Lum Gene Summary [Rat]
Predicted to enable collagen binding activity. Involved in cartilage development; response to Aroclor 1254; and response to growth factor. Predicted to be located in extracellular matrix. Predicted to be part of fibrillar collagen trimer. Predicted to be active in extracellular space. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic cancer. Orthologous to human LUM (lumican). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lum |
| Official Name | lumican [Source:RGD Symbol;Acc:620984] |
| Ensembl ID | ENSRNOG00000004610 |
| Bio databases IDs | |
| Aliases | lumican |
| Synonyms | LDC, lumican, SLRR2D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lum often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- extracellular matrix structural constituent conferring compression resistance
- Leucine rich repeat
- collagen binding
- protein binding
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- neoplasia
- arthritis
- amyotrophic lateral sclerosis
- uterine leiomyoma
- leiomyomatosis
- bruising
- organismal death
- uterine serous papillary cancer
- gait disturbance
role in cell
- differentiation
- proliferation
- migration
- apoptosis
- morphology
- growth
- number
- abnormal morphology
- colony formation
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- cell surface
- lysosomal compartment
- spindle fibers
- extracellular matrix
- plasma
- cartilage matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lum gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transforming growth factor beta1 production
- collagen fibril organization
- positive regulation of transcription from RNA polymerase II promoter
- visual perception
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- fibrillar collagen
- lysosomal lumen
- extracellular matrix
- Golgi lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- extracellular matrix structural constituent conferring compression resistance
- extracellular matrix structural constituent