Slc30a1 Gene Summary [Rat]
Enables calcium channel inhibitor activity and zinc:proton antiporter activity. Involved in several processes, including detoxification of cadmium ion; metal ion transport; and regulation of postsynapse organization. Acts upstream of or within zinc ion transport. Located in T-tubule; dendrite; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and postsynaptic density membrane. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc30a1 |
| Official Name | solute carrier family 30 member 1 [Source:RGD Symbol;Acc:61918] |
| Ensembl ID | ENSRNOG00000004749 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 member 1 |
| Synonyms | C130040I11RIK, HBC647, solute carrier family 30 member 1, solute carrier family 30 (zinc transporter), member 1, ZNT1, ZRC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc30a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- cation diffusion facilitator family transporter
- calcium channel inhibitor
- antiporter
- protein binding
- zinc ion transporter
- cytosolic tail domain
- Cation efflux family
- metal ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast cancer
role in cell
- expression in
- production in
- growth
- homeostasis in
- depolarization
- depolarization in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- organelle
- Cytoplasm
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- basolateral cell surfaces
- synaptic membrane
- basolateral membrane
- nuclear envelope
- synapse
- transverse tubules
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc30a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- positive regulation of dendritic spine morphogenesis
- negative regulation of neurotransmitter secretion
- cellular zinc ion homeostasis
- negative regulation of calcium ion import
- defense response to bacterium
- cellular calcium ion homeostasis
- detoxification of cadmium ion
- in utero embryonic development
- zinc ion transport
- cadmium ion transmembrane transport
- negative regulation of zinc ion import
- zinc ion transmembrane transport
- detoxification of zinc ion
Cellular Component
Where in the cell the gene product is active
- dendrite
- T-tubule
- nuclear membrane
- cytoplasmic vesicle membrane
- cytoplasm
- membrane
- Golgi apparatus
- endoplasmic reticulum
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- zinc ion transmembrane transporter activity
- calcium channel inhibitor activity