Csgalnact1 Gene Summary [Rat]
Predicted to enable hexosyltransferase activity. Predicted to be involved in UDP-N-acetylgalactosamine metabolic process; UDP-glucuronate metabolic process; and chondroitin sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within cartilage development; endochondral ossification; and extracellular matrix organization. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csgalnact1 |
| Official Name | chondroitin sulfate N-acetylgalactosaminyltransferase 1 [Source:RGD Symbol;Acc:1307618] |
| Ensembl ID | ENSRNOG00000013024 |
| Bio databases IDs | |
| Aliases | chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
| Synonyms | 4732435N03Rik, beta4GalNAcT, ChGn, ChGn-1, chondroitin sulfate N-acetylgalactosaminyltransferase 1, chondroitin sulphate N-acetylgalactosaminyltransferase 1, CSGALNAC-T, FLJ11264, Hs.387794, RGD1307618, SDJLABA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Csgalnact1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
- acetylgalactosaminyltransferase
- Chondroitin N-acetylgalactosaminyltransferase
- peptidoglycan glycosyltransferase
- glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
- enzyme
- protein binding
- glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the Csgalnact1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- adenoma formation
- aldosterone producing adrenocortical adenoma
- dementia
- growth failure
- acute myeloid leukemia
- mild skeletal dysplasia with joint laxity and advanced bone age
- rheumatic fever
- dyspnea
regulates
- IL10
- UDP-N-acetyl-D-galactosamine
- proteoglycan
- chondroitin sulfate B proteoglycan
- chondroitin sulfate proteoglycan
- UDP-glucuronic acid
role in cell
- production in
- growth
- abnormal morphology
- organization
- density
- endochondral ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Csgalnact1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- chondroitin sulfate biosynthetic process
- chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- chondroitin sulfate proteoglycan biosynthetic process
- dermatan sulfate proteoglycan biosynthetic process
- UDP-glucuronate metabolic process
- UDP-N-acetylgalactosamine metabolic process
- extracellular matrix organization
- endochondral ossification
- proteoglycan biosynthetic process
- heparin biosynthetic process
- cartilage development
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- glucuronosyltransferase activity
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
- acetylgalactosaminyltransferase activity
- peptidoglycan glycosyltransferase activity