Kcna4 Gene Summary [Rat]
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in several cellular components, including asymmetric synapse; cell surface; and dendrite. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna4 |
| Official Name | potassium voltage-gated channel subfamily A member 4 [Source:RGD Symbol;Acc:2952] |
| Ensembl ID | ENSRNOG00000004918 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily A member 4 |
| Synonyms | HBK4, HK1, HPCN2, HUKII, KCHAN, K+ CHANNEL A, KCNA4L, KCNA8, KV1.4, Kv1.4 α, Kv4, MCIDDS, PCN2, potassium voltage-gated channel, shaker-related subfamily, member 4, potassium voltage-gated channel subfamily A member 4, Rck4, RHK1, RK3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcna4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Ion transport protein
- BTB_POZ
- protein binding
- pore domain
- ion channel
- PSD 95 binding domain
- voltage-gated potassium channel
- subregion I of the P region
- transmembrane domain
- cytosolic tail domain
- voltage-gated ion channel
- S4 voltage-sensor segment
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- heart disease
- seizures
- multiple sclerosis
- unstable angina
- atrial fibrillation
- hemodynamically unstable ventricular tachycardia
- respiratory failure
regulates
- insulin
- potassium channel
- K+
- DLG4
role in cell
- long-term potentiation
- activity
- polarization
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- dendritic spines
- neurites
- juxtaparanodes
- synapse
- membrane rafts
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- presynaptic terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcna4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- initial segment
- voltage-gated potassium channel complex
- dendritic spine
- membrane
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- potassium ion binding
- delayed rectifier potassium channel activity