Snta1 Gene Summary [Rat]
Enables PDZ domain binding activity. Predicted to be involved in several processes, including regulation of sodium ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within neuromuscular junction development and regulation of vasoconstriction by circulating norepinephrine. Located in neuromuscular junction and sarcolemma. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 12; and sudden infant death syndrome. Orthologous to human SNTA1 (syntrophin alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snta1 |
| Official Name | syntrophin, alpha 1 [Source:RGD Symbol;Acc:1307068] |
| Ensembl ID | ENSRNOG00000016062 |
| Bio databases IDs | |
| Aliases | syntrophin, alpha 1 |
| Synonyms | alpha SYNTROPHIN, dJ1187J4.5, LQT12, SNT1, syntrophin, acidic 1, Syntrophin alpha1, syntrophin, alpha 1, syntrophin α 1, syntrophin, α 1, TACIP1, α-1-syntrophin, α SYNTROPHIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- calmodulin binding domain
- canonical PDZ domain
- enzyme binding
- sodium channel regulator
- linker domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- PDZ-domain binding
- ATPase binding
- syntrophin unique domain
- PH domain
- ion channel binding
Pathways
Biological processes and signaling networks where the Snta1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- ischemic injury
- long-QT syndrome
- long QT syndrome type 12
- myeloproliferative disorder
role in cell
- formation
- abnormal morphology
- morphology
- structural integrity
- mobilization in
- swelling
- turnover in
- development
- cleavage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- soluble fraction
- Cytoplasm
- cellular membrane
- cytoplasmic matrix
- microsome
- postsynaptic membrane
- lateral plasma membrane
- neuromuscular junctions
- neurites
- synapse
- sarcolemma
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snta1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- regulation of heart rate
- regulation of vasoconstriction by circulating norepinephrine
- muscle contraction
- regulation of ventricular cardiac muscle cell action potential
- regulation of ventricular cardiomyocyte membrane repolarization
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- anchoring junction
- cytoskeleton
- postsynaptic membrane
- cytoplasm
- sarcolemma
- dystrophin-associated glycoprotein complex
- macromolecular complex
- neuromuscular junction
- syntrophin complex
- intracellular
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- calmodulin binding
- protein binding
- actin binding
- PDZ domain binding
- structural molecule activity
- ion channel binding
- nitric-oxide synthase binding
- ATPase binding