Kcnab2 Gene Summary [Rat]
Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in myoblast differentiation; regulation of potassium ion transmembrane transport; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnab2 |
| Official Name | potassium voltage-gated channel subfamily A regulatory beta subunit 2 [Source:RGD Symbol;Acc:61828] |
| Ensembl ID | ENSRNOG00000011550 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily A regulatory beta subunit 2 |
| Synonyms | AKR6A5, F5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, I2rf5, K channel β 2, KCNA2B, Kcnb3, KV-BETA-2, KV-β-2, Kv β 2.1, potassium voltage-gated channel, shaker-related subfamily, beta member 2, potassium voltage-gated channel, shaker-related subfamily, β member 2, potassium voltage-gated channel subfamily A regulatory beta subunit 2, potassium voltage-gated channel subfamily A regulatory β subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnab2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldo-keto reductase (AKR) superfamily
- binding protein
- aldo-keto reductase
- Aldo/keto reductase family
- potassium channel regulator
- ion channel binding
- protein binding
- voltage-dependent potassium channel beta subunit, animal
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- seizures
- Huntington disease
- COVID-19
- tremor
- cleft lip
role in cell
- differentiation
- conduction
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- microtubules
- tertiary granule membrane
- specific granule membrane
- cytosol
- cytoplasmic face of plasma membrane
- synaptic membrane
- neurites
- axons
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnab2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- regulation of protein localization at cell surface
- NADPH oxidation
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- membrane
- cytosol
- juxtaparanode region of axon
- synapse
- plasma membrane
- tertiary granule membrane
- microtubule
- specific granule membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- aldo-keto reductase (NADP) activity
- ion channel binding
- potassium channel regulator activity