Syne3 Gene Summary [Rat]
Predicted to enable actin filament binding activity and cytoskeleton-nuclear membrane anchor activity. Predicted to be involved in several processes, including establishment of protein localization to membrane; nuclear migration; and regulation of cell shape. Predicted to be located in nuclear membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. Orthologous to human SYNE3 (spectrin repeat containing nuclear envelope family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syne3 |
| Official Name | spectrin repeat containing, nuclear envelope family member 3 [Source:RGD Symbol;Acc:1304563] |
| Ensembl ID | ENSRNOG00000005287 |
| Bio databases IDs | |
| Aliases | spectrin repeat containing, nuclear envelope family member 3 |
| Synonyms | C14orf139, C14orf49, KASH3, LINC00341, LOC105370641, NCRNA00341, Nesp3, nesprin-3, NET53, RGD1304563, spectrin repeat containing nuclear envelope family member 3, spectrin repeat containing, nuclear envelope family member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syne3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- actin filament binding
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, primarily archaeal type
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- outer nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syne3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cytoskeleton organization
- nuclear migration
- establishment of protein localization in membrane
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- cytoplasm
- membrane
- rough endoplasmic reticulum
- nuclear outer membrane
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding