Hyou1 Gene Summary [Rat]
Predicted to enable adenyl-nucleotide exchange factor activity. Involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway and response to hypoxia. Located in smooth endoplasmic reticulum. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hyou1 |
| Official Name | hypoxia up-regulated 1 [Source:RGD Symbol;Acc:621146] |
| Ensembl ID | ENSRNOG00000010944 |
| Bio databases IDs | |
| Aliases | hypoxia up-regulated 1 |
| Synonyms | 30 hypoxia upregulated 1 homologue, AI415631, CAB140, CBP-140, GRP-170, HSP12A, hypoxia up-regulated 1, IMD59, ORP-150 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hyou1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Hsp70 protein
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- non-insulin-dependent diabetes mellitus
- immunodeficiency 59 and hypoglycemia
- metastasis
- insulin resistance
- seizures
- atherosclerosis
- ischemic injury
role in cell
- apoptosis
- quantity
- cell death
- expression in
- survival
- production in
- activation
- cellular infiltration by
- endoplasmic reticulum stress response
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Extracellular Space
- organelle lumens
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum lumen
- smooth endoplasmatic reticulum
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hyou1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- response to ischemia
- cellular response to hypoxia
- protein folding
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- focal adhesion
- smooth endoplasmic reticulum
- endocytic vesicle lumen
- membrane
- endoplasmic reticulum
- endoplasmic reticulum chaperone complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- unfolded protein binding
- adenyl-nucleotide exchange factor activity