Atg7

Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of programmed cell death; and positive regulation of macroautophagy. Located in axon. Used to study cardiac arrest; degenerative disc disease; and high grade glioma. Biomarker of artery disease (multiple); diabetic retinopathy; metabolic dysfunction-associated steatotic liver disease (multiple); neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atg7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Atg7 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Atg7 gene, providing context for its role in the cell.