Brinp1 Gene Summary [Rat]
Predicted to be involved in cellular response to retinoic acid; central nervous system development; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within several processes, including behavioral fear response; maternal behavior; and protein stabilization. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal cell body. Orthologous to human BRINP1 (BMP/retinoic acid inducible neural specific 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brinp1 |
| Official Name | BMP/retinoic acid inducible neural specific 1 [Source:RGD Symbol;Acc:708519] |
| Ensembl ID | ENSRNOG00000005561 |
| Bio databases IDs | |
| Aliases | BMP/retinoic acid inducible neural specific 1 |
| Synonyms | BMP/retinoic acid inducible neural specific 1, bone morphogenic protein/retinoic acid inducible neural specific 1, BRINP, DBC1, DBCCR1, FAM5A, LOC140610 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brinp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BMP/retinoic acid-inducible neural-specific protein
- membrane-attack complex / perforin
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- Parkinson disease
- multiple sclerosis
- bipolar disorder
- growth failure
- hyperactive behavior
role in cell
- phosphorylation in
- apoptosis
- mitosis
- cell death
- proliferation
- quantity
- number
- activation
- development
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- Extracellular Space
- synapse
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brinp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- exploration behavior
- negative regulation of cell cycle
- positive regulation of neuron differentiation
- negative regulation of mitotic cell cycle
- central nervous system neuron development
- brain development
- maternal behavior
- behavioral fear response
- short-term memory
- cellular response to retinoic acid
- negative regulation of neurogenesis
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein binding