Slc6a14 Gene Summary [Rat]
Predicted to enable (R)-carnitine transmembrane transporter activity; carboxylic acid transmembrane transporter activity; and neutral, basic amino acid:sodium:chloride symporter activity. Predicted to be involved in several processes, including (R)-carnitine transmembrane transport; neutral amino acid transport; and sodium ion transmembrane transport. Located in brush border membrane. Biomarker of inflammatory bowel disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SLC6A14 (solute carrier family 6 member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a14 |
| Official Name | solute carrier family 6 member 14 [Source:RGD Symbol;Acc:1561810] |
| Ensembl ID | ENSRNOG00000005687 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 member 14 |
| Synonyms | 1110007A17RIK, 9030613J17Rik, ATB(0+), Atb0+, ATB0plus, BMIQ11, CATB0plus, solute carrier family 6 member 14, solute carrier family 6 (neurotransmitter transporter), member 14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc6a14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic acid transporter
- beta-alanine transporter
- branched-chain amino acid:sodium symporter
- Sodium:neurotransmitter symporter family
- aromatic amino acid transporter
- neutral amino acid transporter
- amine/polyamine transporter
- organic cation transporter
- neutral, cationic amino acid:sodium:chloride symporter
- Solute carrier families 5 and 6-like; solute binding domain
- carnitine transporter
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- ulcerative colitis
- eating disorder
- psoriasis
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc6a14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- beta-alanine transport
- alanine transport
- sodium ion transmembrane transport
- branched-chain aliphatic amino acid transport
- aromatic amino acid transport
- chloride transport
- amino acid transport
- response to toxin
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- vesicle
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- neutral, cationic amino acid:sodium:chloride symporter activity
- alanine transmembrane transporter activity
- aromatic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- branched-chain amino acid:sodium symporter activity
- beta-alanine transmembrane transporter activity