Hnrnpa2b1 Gene Summary [Rat]
Enables DNA polymerase binding activity; G-rich strand telomeric DNA binding activity; and RNA binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and positive regulation of telomere maintenance via telomere lengthening. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpa2b1 |
| Official Name | heterogeneous nuclear ribonucleoprotein A2/B1 [Source:RGD Symbol;Acc:1310403] |
| Ensembl ID | ENSRNOG00000011175 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein A2/B1 |
| Synonyms | 9130414A06Rik, heterogeneous nuclear ribonucleoprotein A2/B1, hnRNP, hnrnp-A, HNRNPA2, HNRNPA2B, hnRNP A2/B1, HNRNPB1, HNRPA2, HNRPA2B1, Hnrpa2b1 (predicted), HNRPB1, IBMPFD2, OPMD2, RNPA2, ROA2, SNRPB1, VDRE-BP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnrnpa2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- low complexity domain
- RNA recognition motif
- nucleic acid binding
- mRNA binding
- protein binding activity, bridging
- enzyme binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- telomeric DNA binding
- RNA binding
- mRNA 3' UTR binding
- single-stranded DNA binding
- Nuclear factor hnRNPA1
Pathways
Biological processes and signaling networks where the Hnrnpa2b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Alzheimer disease
- ovarian cancer
- colorectal cancer
- oculopharyngeal muscular dystrophy type 2
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- aortic valve calcification
role in cell
- expression in
- phosphorylation in
- migration
- proliferation
- colony formation
- differentiation
- binding in
- invasiveness
- production in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- detergent resistant lipid raft fraction
- glutaminergic synapse
- catalytic step 2 spliceosome
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- polysomes
- granules
- cytosol
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear matrix
- Cajal bodies
- telomeres
- chromatin
- perikaryon
- postsynaptic density
- exosomes
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnrnpa2b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- mRNA export from nucleus
- primary miRNA processing
- negative regulation of nuclear mRNA splicing, via spliceosome
- RNA transport
- mRNA processing
- mRNA transport
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- cytoplasm
- membrane
- Cajal body
- nuclear matrix
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- pre-mRNA intronic binding
- protein binding
- RNA binding
- single-stranded telomeric DNA binding
- mRNA 3'-UTR binding