Braf Gene Summary [Rat]
Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Is active in postsynapse. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and papillary thyroid carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Braf |
| Official Name | B-Raf proto-oncogene, serine/threonine kinase [Source:RGD Symbol;Acc:619908] |
| Ensembl ID | ENSRNOG00000010957 |
| Bio databases IDs | |
| Aliases | B-Raf proto-oncogene, serine/threonine kinase |
| Synonyms | 9930012E13RIK, AI447469, B-RAF1, Braf-2, B-Raf proto-oncogene, serine/threonine kinase, Braf transforming gene, C230098H17, C87398, D6Ertd631e, NS7, RAFB, RAFB1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Braf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- enzyme
- Protein kinase domain
- identical protein binding
- dimer interface domain
- Ras-binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- alcohol group acceptor phosphotransferase
- tail domain
- Tyrosine kinase, catalytic domain
- glycine rich domain
- activation domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- autoinhibitory protein domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- CR1 domain
- CR2 domain
- enzyme binding
- calcium ion binding
- CR3 domain
- protein binding
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- Raf-like Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- ERK phosphorylation site
Pathways
Biological processes and signaling networks where the Braf gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cancer Drug Resistance By Drug Efflux
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin A Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HIF1α Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-8 Signaling
- Integrin Signaling
- Melanoma Signaling
- Melatonin Signaling
- NF-κB Signaling
- Ovarian Cancer Signaling
- Polyamine Regulation in Colon Cancer
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- benign neoplasia
- rheumatoid arthritis
- plasma cell myeloma
- breast cancer
- metastatic melanoma
- cutaneous melanoma
- angiosarcoma
- gastroesophageal junction adenocarcinoma
role in cell
- expression in
- migration
- proliferation
- invasion by
- growth
- formation in
- production in
- cell viability
- quantity
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomal fractions
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cilia
- postsynaptic region
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- Mitochondria
- cytosol
- neurites
- perikaryon
- clathrin-coated vesicles
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Braf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermal growth factor receptor signaling pathway
- response to cAMP
- CD4-positive, alpha-beta T cell differentiation
- visual learning
- protein phosphorylation
- stress fiber assembly
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
- head morphogenesis
- face development
- establishment of protein localization in membrane
- negative regulation of neuron apoptotic process
- thymus development
- MAPK cascade
- positive regulation of axonogenesis
- positive regulation of axon regeneration
- cellular response to calcium ion
- myeloid progenitor cell differentiation
- substrate adhesion-dependent cell spreading
- somatic stem cell maintenance
- long-term synaptic potentiation
- negative regulation of endothelial cell apoptotic process
- synaptic vesicle exocytosis
- T cell receptor signaling pathway
- positive regulation of peptidyl-serine phosphorylation
- T cell differentiation in thymus
- positive regulation of substrate adhesion-dependent cell spreading
- response to peptide hormone stimulus
- regulation of cell proliferation
- organ morphogenesis
- ERK1 and ERK2 cascade
- positive regulation of glucose transport
- regulation of T cell differentiation
- thyroid gland development
- positive regulation of stress fiber assembly
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of fibroblast migration
- cellular response to xenobiotic stimulus
- endothelial cell apoptotic process
- negative regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cell body
- mitochondrion
- cytosol
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- scaffold protein binding
- identical protein binding
- protein binding
- calcium ion binding
- MAP kinase kinase activity
- small GTPase binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase binding