Erbb3 Gene Summary [Rat]
Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; mammary gland involution; and positive regulation of D-glucose import. Located in neuronal cell body and postsynaptic membrane. Biomarker of amblyopia; chronic obstructive pulmonary disease; and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erbb3 |
| Official Name | erb-b2 receptor tyrosine kinase 3 [Source:RGD Symbol;Acc:69323] |
| Ensembl ID | ENSRNOG00000004964 |
| Bio databases IDs | |
| Aliases | erb-b2 receptor tyrosine kinase 3 |
| Synonyms | C-erb-b3, EGFR3, erb-b2 receptor tyrosine kinase 3, Erbb3r, erbB3-S, FERLK, HER3, HER-3 (ERBB3), LCCS2, nuc-ErbB3, p180-ErbB3, p45-sErbB3, p85-sErbB3, VSCN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Erbb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Furin-like cysteine rich region
- TM_EGFR-like
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- proline rich domain
- FU
- N-linked glycosylation site
- cytoplasmic domain
- ligand-binding domain
- YEY motif
- intracellular domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- ubiquitin protein ligase binding
- extracellular domain
- Protein kinase (unclassified specificity)
- signaling receptor activity
- Growth factor receptor domain IV
- Protein tyrosine and serine/threonine kinase
- ectodomain
- protein binding
- receptor binding
- protein tyrosine kinase activator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Receptor L domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- Furin-like repeats
- cytosolic tail domain
- substrate binding domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Erbb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- high risk breast cancer
- invasive breast cancer
- lymph node-positive breast cancer
- breast cancer
- non-insulin-dependent diabetes mellitus
- neoplasia
- prostate cancer
- urogenital cancer
- abdominal cancer
role in cell
- cell viability
- expression in
- phosphorylation in
- apoptosis
- proliferation
- survival
- growth
- migration
- number
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- lateral cell surfaces
- basolateral cell surfaces
- apical membrane
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- lateral plasma membrane
- neurofilaments
- synapse
- perikaryon
- neuromuscular synapse
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Erbb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Schwann cell development
- multicellular organismal development
- positive regulation of cell proliferation
- ERBB2-ERBB3 signaling pathway
- myelination
- endocardial cushion development
- neurogenesis
- extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of neuron apoptotic process
- negative regulation of secretion
- heart development
- wound healing
- protein kinase B signaling cascade
- negative regulation of signal transduction
- motor neuron apoptotic process
- positive regulation of cardiac muscle tissue development
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of kinase activity
- negative regulation of motor neuron apoptotic process
- neuron apoptotic process
- Schwann cell differentiation
- signal transduction
- negative regulation of cell adhesion
- cranial nerve development
- peripheral nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of cell proliferation
- negative regulation of apoptotic process
- positive regulation of gene expression
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- lateral plasma membrane
- extracellular space
- ERBB3:ERBB2 complex
- receptor complex
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- identical protein binding
- neuregulin binding
- neuregulin receptor activity
- ErbB-3 class receptor binding
- ATP binding
- protein tyrosine kinase activity
- transmembrane signaling receptor activity
- protein binding
- ubiquitin protein ligase binding
- protein heterodimerization activity
- protein tyrosine kinase activator activity