Grpel1 Gene Summary [Rat]
Enables ATPase activator activity; ATPase binding activity; and identical protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of PAM complex, Tim23 associated import motor. Biomarker of middle cerebral artery infarction. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grpel1 |
| Official Name | GrpE-like 1, mitochondrial [Source:RGD Symbol;Acc:70947] |
| Ensembl ID | ENSRNOG00000006593 |
| Bio databases IDs | |
| Aliases | GrpE-like 1, mitochondrial |
| Synonyms | GREPEL1, GrpE, GrpE1, GrpE#1, GrpE-like 1, mitochondrial, HMGE, mt-GrpE#1, mt-Grpel1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grpel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ATPase binding
- GrpE
- nucleotide exchange factor GrpE
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grpel1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial matrix
- intracellular protein transport
- protein folding
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrial matrix
- mitochondrion
- presequence translocase-associated import motor
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- chaperone binding
- unfolded protein binding
- adenyl-nucleotide exchange factor activity