Grpel1 Gene Summary [Mouse]
Predicted to enable several functions, including ATPase binding activity; adenyl-nucleotide exchange factor activity; and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; bone; midbrain ventricular layer; and submandibular gland primordium. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grpel1 |
| Official Name | GrpE-like 1, mitochondrial [Source:MGI Symbol;Acc:MGI:1334417] |
| Ensembl ID | ENSMUSG00000029198 |
| Bio databases IDs | |
| Aliases | GrpE-like 1, mitochondrial |
| Synonyms | GREPEL1, GrpE, GrpE1, GrpE#1, GrpE-like 1, mitochondrial, HMGE, mt-GrpE#1, mt-Grpel1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grpel1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ATPase binding
- GrpE
- nucleotide exchange factor GrpE
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grpel1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial matrix
- intracellular protein transport
- protein folding
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrial matrix
- mitochondrion
- presequence translocase-associated import motor
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- chaperone binding
- unfolded protein binding
- adenyl-nucleotide exchange factor activity