Ercc6 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and protein tyrosine kinase activator activity. Involved in DNA protection; regulation of transcription elongation by RNA polymerase II; and transcription-coupled nucleotide-excision repair. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of B-WICH complex and transcription elongation factor complex. Predicted to be active in nucleus. Used to study Cockayne syndrome B. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ercc6 |
| Official Name | ERCC excision repair 6, chromatin remodeling factor [Source:RGD Symbol;Acc:1311509] |
| Ensembl ID | ENSRNOG00000030017 |
| Bio databases IDs | |
| Aliases | ERCC excision repair 6, chromatin remodeling factor |
| Synonyms | 4732403I04, ARMD5, C130058G22RIK, CKN2, COFS, COFS1, CSB, CSB-PGBD3, ERCC6-PGBD3, ERCC excision repair 6, chromatin remodeling factor, excision repair cross-complementing rodent repair deficiency, complementation group 6, FLJ13497, LOC282965, POF11, RAD26, UVSS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ercc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding activity, bridging
- SNF2-related domain
- helicase superfamily c-terminal domain
- ATP binding
- enzyme binding
- chromatin binding
- protein binding
- DNA dependent ATPase
- sequence-specific DNA binding
- Helicase conserved C-terminal domain
- acidic domain
- protein tyrosine kinase activator
- DNA binding
- nucleotide-binding domain
- ATPase domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- ubiquitin binding domain
- Transposase IS4
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Ercc6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- papillomatosis
- benign neoplasia
- rheumatoid arthritis
- tumorigenesis
- edema
- microgliosis
role in cell
- phosphorylation in
- expression in
- quantity
- number
- loss
- proliferation
- apoptosis
- differentiation
- cell viability
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- microtubules
- midbody
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ercc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- response to X-ray
- negative regulation of double-strand break repair via nonhomologous end joining
- base-excision repair
- transcription elongation from RNA polymerase I promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- transcription-coupled nucleotide-excision repair
- transcription from RNA polymerase II promoter
- neurogenesis
- JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- response to toxin
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase I promoter
- response to oxidative stress
- chromatin remodeling
- photoreceptor cell maintenance
- DNA protection
- regulation of transcription elongation, DNA-dependent
- response to gamma radiation
- positive regulation of transcription elongation, DNA-dependent
- positive regulation of DNA repair
- pyrimidine dimer repair
- neuron differentiation
- regulation of transcription elongation from RNA polymerase II promoter
- neuron projection development
- DNA damage response, signal transduction resulting in induction of apoptosis
- response to superoxide
- positive regulation of defense response to virus by host
- single strand break repair
- DNA damage checkpoint
- positive regulation of gene expression
- response to UV-B
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- transcription elongation factor complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA helicase activity
- DNA-dependent ATPase activity
- protein binding
- protein tyrosine kinase activator activity
- sequence-specific DNA binding
- chromatin binding