Idh3b Gene Summary [Rat]
Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Idh3b |
| Official Name | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [Source:RGD Symbol;Acc:621881] |
| Ensembl ID | ENSRNOG00000007316 |
| Bio databases IDs | |
| Aliases | isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta |
| Synonyms | C78231, FLJ11043, Idh β, isocitrate dehydrogenase 3 (NAD+) beta, isocitrate dehydrogenase 3 (NAD+) β, Isocitrate dehydrogenase 3 β, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit β, RP46, tumour-related |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Idh3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isocitrate/isopropylmalate dehydrogenase
- electron carrier
- isocitrate dehydrogenase (NAD)
- enzyme
- protein binding
- enzyme activator activity
Pathways
Biological processes and signaling networks where the Idh3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- retinitis pigmentosa type 46
- organismal death
regulates
- D-glucose
- PFKFB3
role in cell
- proliferation
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Idh3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- isocitrate metabolic process
- tricarboxylic acid cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- isocitrate dehydrogenase (NAD+) activity
- NAD binding
- electron carrier activity