Otub1 Gene Summary [Rat]
Predicted to enable several functions, including ubiquitin protein ligase binding activity; ubiquitin-like protein peptidase activity; and ubiquitin-protein transferase inhibitor activity. Involved in cellular response to interleukin-1. Predicted to be located in cytoplasm and membrane. Orthologous to human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otub1 |
| Official Name | OTU deubiquitinase, ubiquitin aldehyde binding 1 [Source:RGD Symbol;Acc:1311329] |
| Ensembl ID | ENSRNOG00000021175 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Synonyms | AI850305, FLJ20113, HSPC263, OTB1, OTU1, OTUBAIN 1, OTU deubiquitinase, ubiquitin aldehyde binding 1, OTU domain, ubiquitin aldehyde binding 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Otub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- peptidase
- enzyme inhibitor activity
- ubiquitin binding
- protein binding
- enzyme regulator activity
- ovarian tumor domain
- NEDD8-specific protease
- Peptidase C65 Otubain
- ubiquitin binding domain
- ubiquitin-specific protease
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- gastric cancer
- psoriasis
- organismal death
- chronic myeloid leukemia
- asphyxiation
- hyperventilation
- tumorigenesis
role in cell
- activation in
- expression in
- apoptosis
- binding in
- migration
- size
- proliferation
- Gap 0-Gap 1 phase
- cell viability
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Otub1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- DNA repair
- negative regulation of double-strand break repair
- proteolysis
- adaptive immune response
- response to DNA damage stimulus
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- NEDD8-specific protease activity
- ubiquitin-protein ligase inhibitor activity