Casp7 Gene Summary [Rat]
Enables cysteine-type peptidase activity. Involved in leukocyte apoptotic process; protein catabolic process; and striated muscle cell differentiation. Predicted to be located in fibrillar center; nucleoplasm; and plasma membrane. Predicted to be active in cytosol; extracellular space; and nucleus. Biomarker of several diseases, including endometritis; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp7 |
| Official Name | caspase 7 [Source:RGD Symbol;Acc:620944] |
| Ensembl ID | ENSRNOG00000056216 |
| Bio databases IDs | |
| Aliases | caspase 7 |
| Synonyms | Caspase-7, CMH-1, ICE-IAP3, ICE-LAP3, LICE2, Lice2 cysteine protease, mCASP-7, MCH3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- catalytic domain
- peptidase
- caspase cleavage site
- allosteric site
- protein binding
- RNA binding
- CASc
- cysteine-type peptidase
- cysteine endopeptidase
- Raptor N-terminal CASPase like domain
- active site
- aspartic endopeptidase
- caspase-7 exosite
Pathways
Biological processes and signaling networks where the Casp7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endoplasmic Reticulum Stress Pathway
- Endothelin-1 Signaling
- HER-2 Signaling in Breast Cancer
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PEDF Signaling
- Sphingosine-1-phosphate Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- vitiligo
- Huntington disease
- acute-on-chronic liver failure
- Alzheimer disease
- acute hepatitis
- acute myeloid leukemia
- cataract
- exencephaly
- primary sclerosing cholangitis
role in cell
- activation in
- expression in
- phosphorylation in
- apoptosis
- binding
- cell death
- growth
- damage
- survival
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- fibrillar center
- Extracellular Space
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- membrane rafts
- perikaryon
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Casp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein catabolic process
- fibroblast apoptotic process
- response to UV
- execution phase of apoptosis
- defense response to bacterium
- positive regulation of neuron apoptotic process
- heart development
- striated muscle cell differentiation
- cellular response to lipopolysaccharide
- proteolysis
- apoptotic process
- protein processing
- protein maturation
- neuron apoptotic process
- lymphocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase activity involved in execution phase of apoptosis
- aspartic-type endopeptidase activity
- RNA binding
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity
- peptidase activity
- cysteine-type endopeptidase activity involved in apoptotic process