Snw1 Gene Summary [Rat]
Predicted to enable several functions, including Notch binding activity; nuclear receptor binding activity; and transcription coregulator activity. Involved in Schwann cell proliferation. Located in chromatin. Part of SMAD protein complex. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snw1 |
| Official Name | SNW domain containing 1 [Source:RGD Symbol;Acc:1561926] |
| Ensembl ID | ENSRNOG00000037998 |
| Bio databases IDs | |
| Aliases | SNW domain containing 1 |
| Synonyms | 2310008B08Rik, Bx42, FUN20, NCOA-62, Prp45, PRPF45, RGD1561926, SKIIP, SKIP, SKIP1, SNW domain containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Snw1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- retinoic acid receptor binding
- transcription co-repressor
- SKIP/SNW domain
- vitamin D receptor binding
- enzyme binding
- androgen receptor binding
- protein binding
- notch binding
Pathways
Biological processes and signaling networks where the Snw1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- apoptosis
- expression in
- proliferation
- activation in
- cell viability
- autophagy in
- differentiation
- survival
- response by
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- cytosol
- spliceosomes
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- nuclear speckles
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Snw1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- positive regulation of transcription from RNA polymerase II promoter
- nuclear mRNA splicing, via spliceosome
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of retinoic acid receptor signaling pathway
- retinoic acid receptor signaling pathway
- negative regulation of transcription, DNA-dependent
- regulation of vitamin D receptor signaling pathway
- cellular response to retinoic acid
- positive regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of vitamin D receptor signaling pathway
- positive regulation of neurogenesis
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- catalytic step 2 spliceosome
- nuclear speck
- spliceosomal complex
- U2-type catalytic step 2 spliceosome
- nuclear matrix
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein binding
- RNA binding
- androgen receptor binding
- SMAD binding
- transcription coactivator activity
- transcription corepressor activity
- vitamin D receptor binding
- Notch binding
- retinoic acid receptor binding
- enzyme binding