Mtmr4 Gene Summary [Rat]
Predicted to enable several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in response to denervation involved in regulation of muscle adaptation. Predicted to be located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Predicted to be active in early phagosome membrane and endosome membrane. Biomarker of muscular atrophy. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtmr4 |
| Official Name | myotubularin related protein 4 [Source:RGD Symbol;Acc:1310306] |
| Ensembl ID | ENSRNOG00000007496 |
| Bio databases IDs | |
| Aliases | myotubularin related protein 4 |
| Synonyms | ESTM44, FYVE-DSP2, mKIAA0647, myotubularin related protein 4, ZFYVE11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtmr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- FYVE zinc finger
- protein serine/threonine phosphatase
- protein phosphatase binding
- Myotubularin-like phosphatase domain
- PTP_DSP_cys
- protein binding
- Pleckstrin homology-like domain
- FYVE domain like superfamily
- phosphatidylinositol-3-phosphatase
- Protein present in Fab1, YOTB, Vac1, and EEA1
- phosphatase
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- dental caries
- uterine leiomyoma
- leiomyomatosis
role in cell
- maturation
- degranulation
- phagocytosis by
- mitochondrial respiration in
- abscission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- cytosol
- endosomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtmr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- regulation of autophagy
- protein dephosphorylation
- phosphatidylinositol biosynthetic process
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of phosphatidylinositol dephosphorylation
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular space
- endosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphatidylinositol-3-phosphatase activity
- protein binding
- protein phosphatase binding
- metal ion binding
- protein tyrosine phosphatase activity
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity