Optn Gene Summary [Rat]
Enables TFIIIA-class transcription factor binding activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to hydrogen peroxide; and regulation of neuron apoptotic process. Located in several cellular components, including Golgi apparatus; neuronal cell body; and perinuclear region of cytoplasm. Biomarker of Parkinson's disease; bladder neck obstruction; proteinuria; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Optn |
| Official Name | optineurin [Source:RGD Symbol;Acc:628886] |
| Ensembl ID | ENSRNOG00000017941 |
| Bio databases IDs | |
| Aliases | optineurin |
| Synonyms | 4930441O07Rik, ALS12, FIP2, GLC1E, HIP7, HYPL, NEMO RELATED, NRP, OPTINEURIN, OPTN isoform 1, TFIIIA-INTP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Optn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin VI binding domain
- C2H2 type zinc-finger
- UBAN motif
- protein binding activity, bridging
- ubiquitin binding
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- transcription factor binding
- coiled-coil domain
- protein binding
- zinc finger domain
- NF-kappa-B essential modulator NEMO
- identical protein binding
Pathways
Biological processes and signaling networks where the Optn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- open-angle glaucoma
- primary open-angle glaucoma
- open angle glaucoma type 1E
- amyotrophic lateral sclerosis
- OPTN-related disorder
- frontotemporal dementia with parkinsonism
- juvenile open angle glaucoma
- weight loss
- amyotrophic lateral sclerosis type 12
role in cell
- apoptosis
- expression in
- phosphorylation in
- proliferation
- transmembrane potential
- activation in
- degradation in
- production in
- growth
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi apparatus component
- Nucleus
- vesicles
- Golgi Apparatus
- granules
- cytoplasmic aggregates
- cytosol
- Golgi membrane
- trans Golgi network
- endosomal membrane
- nucleoplasm
- cytoplasmic vesicles
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Optn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- protein localization in Golgi apparatus
- signal transduction
- Golgi organization
- regulation of I-kappaB kinase/NF-kappaB cascade
- Golgi to plasma membrane protein transport
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- Golgi ribbon formation
- positive regulation of autophagy
- cell death
- negative regulation of receptor recycling
- autophagy
- innate immune response
- cellular response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi apparatus
- Golgi membrane
- recycling endosome membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- K63-linked polyubiquitin binding
- polyubiquitin binding
- protein binding, bridging