Gsdma Gene Summary [Rat]
Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in membrane. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsdma |
| Official Name | gasdermin A [Source:RGD Symbol;Acc:1592062] |
| Ensembl ID | ENSRNOG00000007943 |
| Bio databases IDs | |
| Aliases | gasdermin A |
| Synonyms | FKSG9, gasdermin A, GSDM, GSDM1, Gsdma1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gsdma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- Gasdermin PUB domain
- protein binding
- Gasdermin pore forming domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gsdma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- pyroptosis
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- wide pore channel activity
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding