GSDMA Gene Summary [Human]
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GSDMA |
| Official Name | gasdermin A [Source:HGNC Symbol;Acc:HGNC:13311] |
| Ensembl ID | ENSG00000167914 |
| Bio databases IDs | |
| Aliases | gasdermin A |
| Synonyms | FKSG9, gasdermin A, GSDM, GSDM1, Gsdma1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSDMA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- Gasdermin PUB domain
- protein binding
- Gasdermin pore forming domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSDMA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- pyroptosis
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- wide pore channel activity
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding