Rgn Gene Summary [Rat]
Enables calcium ion binding activity and gluconolactonase activity. Involved in several processes, including negative regulation of hydrolase activity; positive regulation of hydrolase activity; and regulation of primary metabolic process. Predicted to be located in cytoplasm and nucleus. Used to study familial hyperlipidemia. Biomarker of hepatocellular carcinoma. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgn |
| Official Name | regucalcin [Source:RGD Symbol;Acc:3560] |
| Ensembl ID | ENSRNOG00000007949 |
| Bio databases IDs | |
| Aliases | regucalcin |
| Synonyms | GNL, HEL-S-41, RC, Reguc, regucalcin, senescence marker protein-30, SMP-30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMP-30/Gluconolactonase/LRE-like region
- zinc ion binding
- calcium ion binding
- enzyme
- gluconolactonase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- epithelial cancer
- central nervous system cancer
- liver cancer
- non-small cell lung carcinoma
- non-small cell lung cancer
- hepatocellular carcinoma
- urothelial cancer
- transitional cell carcinoma of kidney
- renal cancer
role in cell
- proliferation
- cell death
- apoptosis
- invasion
- differentiation
- abnormal morphology
- sensitivity
- homeostasis in
- mineralization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ATPase activity
- spermatogenesis
- negative regulation of nitric oxide biosynthetic process
- cellular calcium ion homeostasis
- positive regulation of fatty acid biosynthetic process
- positive regulation of glucose metabolic process
- positive regulation of triglyceride biosynthetic process
- kidney development
- negative regulation of apoptotic process
- negative regulation of protein phosphorylation
- negative regulation of epithelial cell proliferation
- regulation of calcium-mediated signaling
- L-ascorbic acid biosynthetic process
- negative regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- calcium ion binding
- gluconolactonase activity
- enzyme regulator activity