Prf1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in circadian rhythm and response to ethanol. Located in extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prf1 |
| Official Name | perforin 1 [Source:RGD Symbol;Acc:708463] |
| Ensembl ID | ENSRNOG00000000562 |
| Bio databases IDs | |
| Aliases | perforin 1 |
| Synonyms | CYTA, HPLH2, P1, Perforin, perforin 1, perforin 1 (pore forming protein), Perforin A, Pfn, PFP, RATCYTA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- membrane-attack complex / perforin
- MAC/Perforin domain
- calcium ion binding
- protein binding
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Prf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Graft-versus-Host Disease Signaling
- Granzyme A Signaling
- Granzyme B Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- cancer
- epithelial cancer
- skin cancer
- psoriasis
- graft-vs-host disease
- splenomegaly
- infection
- rheumatoid arthritis
- metastasis
role in cell
- necrosis
- cell death
- apoptosis
- transmembrane potential
- killing
- killing by
- production in
- expression in
- quantity
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- organelle lumens
- cellular membrane
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- immunological synapses
- granules
- cytosol
- cytotoxic granule
- dense-core vesicles
- cytoplasmic vesicles
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- protein homooligomerization
- protein secretion
- immunological synapse formation
- cellular defense response
- defense response to tumor cell
- apoptotic process
- immune response to tumor cell
- T cell mediated cytotoxicity
- killing of cells of other organism
- defense response to virus
- positive regulation of killing of cells of other organism
- protein import
Cellular Component
Where in the cell the gene product is active
- cytolytic granule
- endosome lumen
- membrane
- cytosol
- extracellular region
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- wide pore channel activity
- identical protein binding
- protein binding
- calcium ion binding