Ifngr2 Gene Summary [Rat]
Predicted to enable type II interferon receptor activity. Involved in microglial cell activation and positive regulation of NMDA glutamate receptor activity. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 28. Orthologous to human IFNGR2 (interferon gamma receptor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifngr2 |
| Official Name | interferon gamma receptor 2 [Source:RGD Symbol;Acc:1307532] |
| Ensembl ID | ENSRNOG00000002032 |
| Bio databases IDs | |
| Aliases | interferon gamma receptor 2 |
| Synonyms | AF-1, IFGR2, Ifgt, IFNgammaRbeta, IFN gamma R beta 1, IFNGRB, IFNGT1, IFN γ R β 1, IMD28, interferon gamma receptor 2, interferon γ receptor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifngr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interferon-gamma receptor
- FN3
- protein binding
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ifngr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-10 Signaling
- iNOS Signaling
- Interferon Signaling
- Neuroinflammation Signaling Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- COVID-19
- lung cancer
- pulmonary fibrosis
- inflammatory bowel disease
- peritoneal carcinoma
- antineutrophil cytoplasmic antibody-associated vasculitis
- paralytic autoimmune myositis
- infection
role in cell
- cytotoxicity
- function
- activation
- development
- differentiation
- class switching
- signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifngr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microglial cell activation
- interferon-gamma-mediated signaling pathway
- cytokine-mediated signaling pathway
- defense response to virus
- cell surface receptor signaling pathway
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor activity
- cytokine receptor activity