Eomes Gene Summary [Rat]
Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including gastrulation; nervous system development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including endoderm formation; nervous system development; and trophectodermal cell differentiation. Predicted to be active in chromatin and nucleus. Orthologous to human EOMES (eomesodermin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eomes |
| Official Name | eomesodermin [Source:RGD Symbol;Acc:1359706] |
| Ensembl ID | ENSRNOG00000042140 |
| Bio databases IDs | |
| Aliases | eomesodermin |
| Synonyms | EOMESODERMIN, TBR-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eomes often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- T-box transcription factor-associated
- nucleic acid binding
- transcription co-repressor
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- T-box
- double-stranded DNA binding
- DNA-binding domain of the T-box transcription factor family
- transcription factor activity
Pathways
Biological processes and signaling networks where the Eomes gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- diabetic nephropathy
- hepatitis C
- exhaustion
- polymicrogyria
- susceptibility to rheumatoid arthritis
- acute myeloid leukemia
- immune thrombocytopenia
role in cell
- expression in
- migration
- cell death
- production in
- production
- differentiation
- development
- elimination
- expansion
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intracellular space
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eomes gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- cerebral cortex neuron differentiation
- cerebral cortex regionalization
- negative regulation of transcription from RNA polymerase II promoter
- mesodermal to mesenchymal transition involved in gastrulation
- chromatin remodeling
- neuron migration
- skeletal muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- cell differentiation involved in embryonic placenta development
- endoderm formation
- mesoderm formation
- mesendoderm development
- trophectodermal cell differentiation
- stem cell maintenance
- astrocyte differentiation
- adaptive immune response
- negative regulation of sequence-specific DNA binding transcription factor activity
- brain development
- regulation of transcription from RNA polymerase II promoter
- CD8-positive, alpha-beta T cell differentiation involved in immune response
- endodermal cell fate specification
- gene expression
- cardioblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- chromatin DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity