Slc9a8 Gene Summary [Rat]
Enables sodium:proton antiporter activity. Involved in proton transmembrane transport; regulation of intracellular pH; and sodium ion transmembrane transport. Located in apical plasma membrane. Orthologous to human SLC9A8 (solute carrier family 9 member A8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc9a8 |
| Official Name | solute carrier family 9 member A8 [Source:RGD Symbol;Acc:1308193] |
| Ensembl ID | ENSRNOG00000008354 |
| Bio databases IDs | |
| Aliases | solute carrier family 9 member A8 |
| Synonyms | 1200006P13Rik, 6430709P13Rik, NHE-8, solute carrier family 9 member A8, solute carrier family 9 (sodium/hydrogen exchanger), member 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc9a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium/hydrogen exchanger family
- potassium:hydrogen antiporter
- sodium/hydrogen exchanger 3
- protein binding
- transporter
- sodium:hydrogen antiporter
Pathways
Biological processes and signaling networks where the Slc9a8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- multiple sclerosis
- amyotrophic lateral sclerosis
- dextran sodium sulfate-induced colitis
- globozoospermia
- susceptibility to amyotrophic lateral sclerosis
- asthenozoospermia
regulates
- Na+
- H+
- ion
role in cell
- abnormal morphology
- lack
- assembly
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- apical membrane
- Golgi membrane
- medial Golgi compartments
- trans Golgi network
- acrosome
- multivesicular bodies
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc9a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- ion transport
- regulation of intracellular pH
- potassium ion transmembrane transport
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- Golgi membrane
- multivesicular body membrane
- apical plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- potassium:hydrogen antiporter activity
- sodium:hydrogen antiporter activity