Ica1 Gene Summary [Rat]
Enables protein domain specific binding activity. Involved in regulation of protein-containing complex assembly. Located in Golgi apparatus; dendrite; and perinuclear region of cytoplasm. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ica1 |
| Official Name | islet cell autoantigen 1 [Source:RGD Symbol;Acc:621465] |
| Ensembl ID | ENSRNOG00000008628 |
| Bio databases IDs | |
| Aliases | islet cell autoantigen 1 |
| Synonyms | ICA69, ICAp69, islet cell autoantigen 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ica1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arfaptin-like domain
- protein domain specific binding
- protein binding
- Islet cell autoantigen ICA69, C-terminal domain
- Bin/Amphiphysin/Rvs domain
Pathways
Biological processes and signaling networks where the Ica1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- systemic lupus erythematosus
- diabetes mellitus
- psoriasis
- insulin-dependent diabetes mellitus
- Huntington disease
- pneumonia
regulates
- D-glucose
- protein-protein complex
- proinsulin
- water
role in cell
- activation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- perinuclear region
- secretory granule membrane
- cytosol
- Golgi membrane
- Golgi stacks
- trans Golgi network
- insulin secretory granules
- synaptic vesicles
- perinuclear vesicles
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ica1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- regulation of transport
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Golgi membrane
- Golgi apparatus
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding