Nelfe Gene Summary [Rat]
Enables chromatin binding activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of protein modification process; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body and plasma membrane. Predicted to be part of NELF complex. Predicted to be active in chromatin and nucleus. Orthologous to human NELFE (negative elongation factor complex member E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nelfe |
| Official Name | negative elongation factor complex member E [Source:RGD Symbol;Acc:1303325] |
| Ensembl ID | ENSRNOG00000000420 |
| Bio databases IDs | |
| Aliases | negative elongation factor complex member E |
| Synonyms | D17H6S45, D6S45, negative elongation factor complex member E, negative elongation factor complex member E, Rdbp, RD, RDBP, RDP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nelfe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- chromatin binding
- protein binding
- phosphorylation site
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- age-related macular degeneration
- metastasis
- irritable bowel syndrome
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
role in cell
- proliferation
- synthesis in
- growth
- expression in
- colony formation
- recruitment in
- trimethylation in
- acetylation in
- binding in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Plasma Membrane
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nelfe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of protein modification process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- NELF complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- chromatin binding