Cbx1 Gene Summary [Rat]
Predicted to enable several functions, including histone methyltransferase binding activity; identical protein binding activity; and methylated histone binding activity. Predicted to be involved in DNA damage response and heterochromatin formation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in several cellular components, including chromocenter; chromosome; and pronucleus. Predicted to be active in pericentric heterochromatin. Orthologous to human CBX1 (chromobox 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx1 |
| Official Name | chromobox 1 [Source:RGD Symbol;Acc:1310714] |
| Ensembl ID | ENSRNOG00000008689 |
| Bio databases IDs | |
| Aliases | chromobox 1 |
| Synonyms | CBX, Cbx-rs2, chromobox 1, E430007M08RIK, HETEROCHROMATIN protein p25, HP1B, HP1-BETA, HP1Hs-beta, HP1Hs-β, HP1-β, M31, MOD1, Modifier 1, p25beta, Similar to m31 or mod1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cbx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromo shadow domain
- Chromatin organization modifier domain
- transcription regulator
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- hinge domain
- enzyme binding
- chromatin binding
- protein binding
- identical protein binding
- Chromo (CHRromatin organization MOdifier) domain
Pathways
Biological processes and signaling networks where the Cbx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diverticular disease
- organismal death
- prostate cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- binding in
- expression in
- transcription in
- differentiation
- growth
- assembly
- G1 phase
- trimethylation in
- DNA damage response
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- intracellular membrane-bounded organelle
- spindle apparatus
- Cytoplasm
- nuclear foci
- chromosome
- sister chromatids
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- spindle pole
- XY bodies
- pronucleus
- mitotic spindle
- centromeres
- telomeres
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cbx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nuclear body
- chromosome, centromeric region
- chromatin
- centromeric heterochromatin
- nucleoplasm
- chromosome, telomeric region
- heterochromatin
- nucleus
- male pronucleus
- intracellular membrane-bounded organelle
- chromocenter
- spindle
- female pronucleus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- methylated histone residue binding
- chromatin binding
- enzyme binding