Atp6v0d1 Gene Summary [Rat]
Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in several processes, including cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and synaptic vesicle lumen acidification. Located in apical plasma membrane; axon terminus; and synaptic vesicle. Part of protein-containing complex. Is active in synaptic vesicle membrane. Orthologous to human ATP6V0D1 (ATPase H+ transporting V0 subunit d1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0d1 |
| Official Name | ATPase H+ transporting V0 subunit D1 [Source:RGD Symbol;Acc:1306159] |
| Ensembl ID | ENSRNOG00000017235 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V0 subunit D1 |
| Synonyms | Ac39, ATP6D, ATP6DV, ATPase, H+ transporting, lysosomal V0 subunit D1, ATPase H+ transporting V0 subunit D1, LOC100132855, P39, V-ATPase V0-d1, VATX, VMA6, VPATPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v0d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Protein of unknown function (DUF2764)
- H+-transporting two-sector ATPase
- ATP synthase (C/AC39) subunit
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0d1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- age-related macular degeneration
- Alzheimer disease
- psoriasis
- Parkinson disease
- infection by vesicular stomatitis virus
role in cell
- growth
- replication in
- Clathrin mediated endocytosis by
- homeostasis in
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- cellular membrane
- vesicles
- centrosome
- apical membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- early endosomes
- microsomal membrane
- axon terminals
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v0d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- cilium morphogenesis
- regulation of macroautophagy
- vacuolar transport
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- plasma membrane proton-transporting V-type ATPase complex
- lysosomal membrane
- axon terminus
- vacuolar proton-transporting V-type ATPase, V0 domain
- early endosome
- centrosome
- extracellular vesicular exosome
- membrane
- vacuolar proton-transporting V-type ATPase complex
- phagocytic vesicle membrane
- endosome membrane
- synaptic vesicle membrane
- apical plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism