Smarca5 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and nucleosome array spacer activity. Predicted to contribute to histone binding activity. Predicted to be involved in several processes, including antiviral innate immune response; negative regulation of mitotic chromosome condensation; and regulation of macromolecule metabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; chromatin remodeling; and positive regulation of DNA-templated transcription. Predicted to be located in chromosome and nuclear lumen. Predicted to be part of nucleus. Predicted to be active in chromatin; nucleus; and site of double-strand break. Orthologous to human SMARCA5 (SNF2 related chromatin remodeling ATPase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarca5 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [Source:RGD Symbol;Acc:1308832] |
| Ensembl ID | ENSRNOG00000018149 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 |
| Synonyms | 4933427E24Rik, D030040M08RIK, D330027N15Rik, hISWI, hSNF2H, ISWI, MommeD4, SNF2H, SNF2 related chromatin remodeling ATPase 5, SNFA5, WCRF135 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smarca5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- histone binding
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- HAND
- helicase
- DEAD/DEAH box helicase
- SNF2-related domain
- helicase superfamily c-terminal domain
- SLIDE
- ATP binding
- protein binding
- DNA dependent ATPase
- ATPase
- Helicase conserved C-terminal domain
- DNA binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Smarca5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- liver cancer
- epithelial cancer
- schizophrenia
- postmenopausal osteoporosis
- hepatocellular carcinoma
- mental retardation
- localization-related epilepsy
- neurodevelopmental disorder
role in cell
- expression in
- activation in
- growth
- apoptosis
- cell death
- assembly
- formation
- development
- remodeling
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- fibrillar center
- nuclear foci
- chromosome
- nucleoplasm
- DNA replication foci
- centromeres
- replication fork
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smarca5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of transcription, DNA-dependent
- positive regulation of DNA replication
- transcription initiation, DNA-dependent
- regulation of DNA replication
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase III promoter
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
- methylation-dependent chromatin silencing
- positive regulation of transcription from RNA polymerase I promoter
- chromatin remodeling
- chromatin silencing at rDNA
- heterochromatin assembly
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- nuclear replication fork
- nucleolus
- chromatin silencing complex
- centromeric heterochromatin
- fibrillar center
- chromatin accessibility complex
- nucleoplasm
- condensed chromosome
- nucleus
- ACF complex
- RSF complex
- NURF complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- protein binding
- histone binding
- nucleosome binding
- helicase activity