Fgf22 Gene Summary [Rat]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | Fgf22 |
| Official Name | fibroblast growth factor 22 [Source:RGD Symbol;Acc:620177] |
| Ensembl ID | ENSRNOG00000008960 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 22 |
| Synonyms | 2210414E06Rik, Fgf5d, fibroblast growth factor 22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgf22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf22 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epileptic seizure
- seizures
- androgenic alopecia
regulated by
- telmisartan
- letrozole
role in cell
- differentiation
- maturation
- production in
- abnormal quantity
- abnormal morphology
- differentiation in
- clustering
- paired-pulse facilitation
- synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- postsynaptic region
- Plasma Membrane
- Golgi Apparatus
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgf22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of cell proliferation
- cell differentiation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- regulation of cell migration
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- fibroblast growth factor receptor binding