Hamp Gene Summary [Rat]
Predicted to enable copper ion binding activity; hormone activity; and iron ion transmembrane transporter inhibitor activity. Involved in several processes, including cellular response to X-ray; cellular response to bile acid; and cellular response to cytokine stimulus. Located in apical cortex; extracellular space; and intercalated disc. Used to study anemia and hepatocellular carcinoma. Biomarker of several diseases, including anemia (multiple); end stage renal disease; extrahepatic cholestasis; liver disease (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in hemochromatosis; hemochromatosis type 2B; and hepatocellular carcinoma. Orthologous to human HAMP (hepcidin antimicrobial peptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hamp |
| Official Name | hepcidin antimicrobial peptide [Source:RGD Symbol;Acc:70971] |
| Ensembl ID | ENSRNOG00000021029 |
| Bio databases IDs | |
| Aliases | hepcidin antimicrobial peptide |
| Synonyms | Hamp1, HEPC, Hepc1, HEPCIDIN, hepcidin antimicrobial peptide, HFE2B, LEAP1, PLTR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hamp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Hepcidin
- hormone
- receptor binding
Pathways
Biological processes and signaling networks where the Hamp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- memory deficits
- liver cancer
- type 2B hemochromatosis
- rheumatoid arthritis
- anisocytosis
- gestational diabetes mellitus
- juvenile hemochromatosis
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- expression in
- activation
- proliferation
- cellular infiltration by
- abnormal morphology
- organismal death
- homeostasis
- binding in
- homeostasis in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- intercellular junctions
- apical cortex
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hamp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- negative regulation of iron ion transmembrane transport
- negative regulation of inflammatory response
- protein catabolic process
- transcription from RNA polymerase II promoter
- positive regulation of protein catabolic process
- myeloid cell homeostasis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of bone resorption
- defense response to bacterium
- macrophage activation
- JAK-STAT cascade
- cellular iron ion homeostasis
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- immune response
- positive regulation of macrophage activation
- killing of cells of other organism
- response to iron ion
- establishment of localization in cell
- defense response to fungus
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- copper ion binding
- hormone activity