Fgf22 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in regulation of synapse maturation and trans-synaptic signaling. Located in Golgi apparatus; cell surface; and nucleolus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Is extrinsic component of postsynaptic density membrane. Is expressed in brain; early conceptus; gonad; spinal cord; and tongue. Orthologous to human FGF22 (fibroblast growth factor 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf22 |
| Official Name | fibroblast growth factor 22 [Source:MGI Symbol;Acc:MGI:1914362] |
| Ensembl ID | ENSMUSG00000020327 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 22 |
| Synonyms | 2210414E06Rik, Fgf5d, fibroblast growth factor 22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epileptic seizure
- seizures
- androgenic alopecia
regulated by
- telmisartan
- letrozole
role in cell
- differentiation
- maturation
- production in
- abnormal quantity
- abnormal morphology
- differentiation in
- clustering
- paired-pulse facilitation
- synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- postsynaptic region
- Plasma Membrane
- Golgi Apparatus
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of cell proliferation
- cell differentiation
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- regulation of cell migration
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- fibroblast growth factor receptor binding