Pyy Gene Summary [Rat]
Predicted to enable neuropeptide Y receptor binding activity and neuropeptide hormone activity. Involved in negative regulation of response to food. Located in extracellular space. Orthologous to several human genes including PYY (peptide YY). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pyy |
| Official Name | peptide YY (mapped) [Source:RGD Symbol;Acc:1593289] |
| Ensembl ID | ENSRNOG00000020877 |
| Bio databases IDs | |
| Aliases | peptide YY (mapped) |
| Synonyms | GHYY, peptide-YY, PYY1, PYY-I, RATGHYY, Yy |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pyy often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAH
- G-protein-coupled receptor binding
- hormone
- protein binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Pyy gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperammonemia type III
- weight gain
- weight loss
- obesity
- diabetic nephropathy
- morbid obesity
- colorectal cancer
- tinnitus
- hyperphagia
- diverticular disease
role in cell
- production in
- quantity
- proliferation
- migration
- cell death
- accumulation
- differentiation
- contraction
- rearrangement
- hyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pyy gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- intestinal epithelial cell differentiation
- feeding behavior
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- neuropeptide hormone activity
- hormone activity
- neuropeptide Y receptor binding