Dgat1 Gene Summary [Rat]
Enables diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgat1 |
| Official Name | diacylglycerol O-acyltransferase 1 [Source:RGD Symbol;Acc:628673] |
| Ensembl ID | ENSRNOG00000028711 |
| Bio databases IDs | |
| Aliases | diacylglycerol O-acyltransferase 1 |
| Synonyms | AGRP1, ARAT, ARGP1, D15Ertd23e, Dagt1, DGAT, DIACYLGLYCERIDE ACYLTRANSFERASE, DIACYLGLYCEROL ACYLTRANSFERASE, Diacylglycerol o-acyltransferase 1, DIAR7, LOC100131064, LOC100133107, LOC727765 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dgat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- retinol O-fatty-acyltransferase
- diacylglycerol binding
- fatty acid binding
- 2-acylglycerol O-acyltransferase
- diacylglycerol O-acyltransferase
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- transferase, transferring acyl groups
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- non-insulin-dependent diabetes mellitus
- hepatic steatosis
- hereditary disorder
- diarrhea type 7
- dermatological disorder
- nonalcoholic fatty liver disease
- alopecia
- insulin resistance
- obesity
role in cell
- apoptosis
- expression in
- synthesis in
- accumulation in
- quantity
- activation
- binding in
- formation in
- ferroptosis
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- specific granule membrane
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dgat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- fatty acid homeostasis
- triglyceride biosynthetic process
- retinol metabolic process
- monoacylglycerol biosynthetic process
- very-low-density lipoprotein particle assembly
- triglyceride metabolic process
- long-chain fatty-acyl-CoA metabolic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- identical protein binding
- protein binding
- 2-acylglycerol O-acyltransferase activity
- retinol O-fatty-acyltransferase activity
- diacylglycerol O-acyltransferase activity