Alg6 Gene Summary [Rat]
Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg6 |
| Official Name | ALG6, alpha-1,3-glucosyltransferase [Source:RGD Symbol;Acc:1308815] |
| Ensembl ID | ENSRNOG00000009045 |
| Bio databases IDs | |
| Aliases | ALG6, alpha-1,3-glucosyltransferase |
| Synonyms | ALG6 alpha-1,3-glucosyltransferase, ALG6, alpha-1,3-glucosyltransferase, ALG6 α-1,3-glucosyltransferase, ALG6, α-1,3-glucosyltransferase, BX005053.5, CDG1C, E230028F23RIK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alg6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
- Dol-P-Glc:Man9GlcNAc2-PP-Dol α-1,3-glucosyltransferase
- glucosyltransferase
- enzyme
- protein binding
- dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase
- ALG6, ALG8 glycosyltransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- PROM1
- oligosaccharide-diphosphodolichol
regulated by
disease
- adenoma formation
- congenital disorder of glycosylation type 1c
- hereditary disorder
- cystic kidney disease
- aldosterone producing adrenocortical adenoma
role in cell
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alg6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligosaccharide-lipid intermediate biosynthetic process
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
- dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
- glucosyltransferase activity