Tax1bp1 Gene Summary [Rat]
Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Involved in negative regulation of apoptotic process. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tax1bp1 |
| Official Name | Tax1 binding protein 1 [Source:RGD Symbol;Acc:708579] |
| Ensembl ID | ENSRNOG00000008393 |
| Bio databases IDs | |
| Aliases | Tax1 binding protein 1 |
| Synonyms | 1200003J11Rik, 1700069J21RIK, Aa1076, CALCOCO3, D6Ertd404e, D6ERTD772E, LOC246244, T6BP, Tax1 binding protein 1, Tax1 (human T cell leukaemia virus type I) binding protein 1, Tax1 (human T cell leukemia virus type I) binding protein 1, Txbp1, TXBP151 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tax1bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SKICH domain
- Afadin- and alpha -actinin-Binding
- PPXY motif
- Hyaluronan mediated motility receptor N-terminal
- protein binding activity, bridging
- coiled-coil domain
- protein binding
- RIM-binding protein of the cytomatrix active zone
- kinase binding
- tankyrase binding domain
- Zn-C2H2_CALCOCO1_TAX1BP1_like
- zinc finger domain
- Intermediate filament protein
- Autophagy receptor zinc finger-C2H2 domain
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- prostate cancer
- T-cell leukemia
- polycystic ovary syndrome
- hypospadia
- T acute lymphoblastic leukemia
- hypersensitive reaction
- weight gain
role in cell
- production in
- activation in
- ubiquitination in
- binding in
- apoptosis
- recruitment
- function
- incorporation in
- K63 polyubiquitination in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tax1bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of toll-like receptor 4 signaling pathway
- autophagy
- negative regulation of apoptotic process
- innate immune response
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- pre-autophagosomal structure
- mitochondrion
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein binding, bridging
- kinase binding