Ifi27 Gene Summary [Rat]
Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in maternal process involved in female pregnancy; response to cytokine; and response to estradiol. Predicted to be located in nuclear inner membrane. Predicted to be active in mitochondrial membrane. Orthologous to human IFI27 (interferon alpha inducible protein 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifi27 |
| Official Name | interferon, alpha-inducible protein 27 [Source:RGD Symbol;Acc:69404] |
| Ensembl ID | ENSRNOG00000009263 |
| Bio databases IDs | |
| Aliases | interferon, alpha-inducible protein 27 |
| Synonyms | FAM14D, IFI27L, Ifi27l1, interferon alpha inducible protein 27, interferon, alpha-inducible protein 27, interferon α inducible protein 27, interferon, α-inducible protein 27, IRG1, ISG12, ISG12A, isg12(a), P27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifi27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced 6-16 family
- lamin binding
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- septic shock
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lichen planus
- atopic dermatitis
- systemic lupus erythematosus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- psoriasis
- primary myelofibrosis
regulates
- RNA polymerase II
- proteasome
- DNA promoter
- DNA endogenous promoter
role in cell
- apoptosis
- invasion by
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- inner nuclear membrane
- nuclear envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifi27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- innate immune response
- apoptotic process
- extrinsic apoptotic signaling pathway
- pyroptosis
- apoptotic signaling pathway
- defense response to virus
- regulation of protein export from nucleus
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nuclear inner membrane
- mitochondrial membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lamin binding
- binding, bridging