Stat1 Gene Summary [Rat]
Enables sequence-specific DNA binding activity. Acts upstream of or within cellular response to cytokine stimulus. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study obesity. Biomarker of asthma; chronic obstructive pulmonary disease; and metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stat1 |
| Official Name | signal transducer and activator of transcription 1 [Source:RGD Symbol;Acc:3771] |
| Ensembl ID | ENSRNOG00000014079 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 1 |
| Synonyms | DPMC, signal transducer and activator of transcription 4, SLEB11, STAT4 alpha, STAT4 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- STAT protein, DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- SPXX motif
- STAT protein, all-alpha domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the Stat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Dendritic Cell Maturation
- EGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- GM-CSF Signaling
- Growth Hormone Signaling
- IL-15 Production
- IL-22 Signaling
- IL-3 Signaling
- IL-7 Signaling Pathway
- IL-9 Signaling
- iNOS Signaling
- Interferon Signaling
- JAK/Stat Signaling
- Natural Killer Cell Signaling
- Oncostatin M Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- T Helper Cell Differentiation
- TEC Kinase Signaling
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- Thrombopoietin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- rheumatoid arthritis
- Alzheimer disease
- celiac disease
- thyroid disease
- systemic lupus erythematosus
- epithelial cancer
- insulin-dependent diabetes mellitus
- diabetes mellitus
- sporadic amyotrophic lateral sclerosis
role in cell
- production in
- cytotoxicity
- expression in
- apoptosis
- activation in
- proliferation
- survival
- growth
- killing
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 cell differentiation
- cytokine-mediated signaling pathway
- response to interleukin-6
- positive regulation of transcription from RNA polymerase II promoter
- defense response
- response to peptide hormone stimulus
- regulation of cell proliferation
- interleukin-12-mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity