Mdm4 Gene Summary [Rat]
Predicted to enable enzyme binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of macromolecule metabolic process; and protein stabilization. Predicted to act upstream of or within heart development; positive regulation of cell population proliferation; and regulation of heart rate. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Orthologous to human MDM4 (MDM4 regulator of p53). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdm4 |
| Official Name | MDM4 regulator of p53 [Source:RGD Symbol;Acc:1309306] |
| Ensembl ID | ENSRNOG00000009696 |
| Bio databases IDs | |
| Aliases | MDM4 regulator of p53 |
| Synonyms | 4933417N07RIK, BMFS6, HDMX, LOC102633382, MDM4 regulator of p53, MDMX, MRP1, transformed mouse 3T3 cell double minute 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mdm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- enzyme binding
- protein binding
- Mdm2 protein binding domain
- acidic domain
- phosphorylation site
- Zn-finger in Ran binding protein and others
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger domain
- p53-binding domain
- SWIB/MDM2 domain family
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Mdm4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- thrombocytopenia
- tumorigenesis
- actinic keratosis
- metastatic breast cancer
- colon cancer
- melanoma cancer
- cancer
- prostate cancer
- Alzheimer disease
role in cell
- cell death
- apoptosis
- expression in
- proliferation
- colony formation
- degradation in
- loss
- cell viability
- phosphorylation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mdm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- heart valve development
- atrioventricular valve morphogenesis
- negative regulation of cell proliferation
- ventricular septum development
- atrial septum development
- negative regulation of protein catabolic process
- endocardial cushion morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- regulation of cell cycle
- cellular response to hypoxia
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- enzyme binding