IFI27 Gene Summary [Human]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in several processes, including cellular protein metabolic process; defense response to other organism; and extrinsic apoptotic signaling pathway. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of protein export from nucleus. Located in mitochondrial membrane and nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IFI27 |
| Official Name | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] |
| Ensembl ID | ENSG00000165949 |
| Bio databases IDs | |
| Aliases | interferon alpha inducible protein 27 |
| Synonyms | FAM14D, IFI27L, Ifi27l1, interferon alpha inducible protein 27, interferon, alpha-inducible protein 27, interferon α inducible protein 27, interferon, α-inducible protein 27, IRG1, ISG12, ISG12A, isg12(a), P27 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFI27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced 6-16 family
- lamin binding
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- septic shock
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- lichen planus
- atopic dermatitis
- systemic lupus erythematosus
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- psoriasis
- primary myelofibrosis
regulates
- RNA polymerase II
- proteasome
- DNA promoter
- DNA endogenous promoter
role in cell
- apoptosis
- invasion by
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- inner nuclear membrane
- nuclear envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFI27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- innate immune response
- apoptotic process
- extrinsic apoptotic signaling pathway
- pyroptosis
- apoptotic signaling pathway
- defense response to virus
- regulation of protein export from nucleus
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nuclear inner membrane
- mitochondrial membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lamin binding
- binding, bridging