Srp68 Gene Summary [Rat]
Predicted to enable 7S RNA binding activity; protein domain specific binding activity; and signal recognition particle binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane and response to xenobiotic stimulus. Predicted to be located in cytosol and focal adhesion. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human SRP68 (signal recognition particle 68). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srp68 |
| Official Name | signal recognition particle 68 [Source:RGD Symbol;Acc:1305376] |
| Ensembl ID | ENSRNOG00000009351 |
| Bio databases IDs | |
| Aliases | signal recognition particle 68 |
| Synonyms | 2610024I03RIK, LOC103690039, SCN10, signal recognition particle 68 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Srp68 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 7S RNA binding
- signal recognition particle binding
- ribosome binding
- protein domain specific binding
- protein binding
- RNA-binding domain of signal recognition particle subunit 68
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- focal adhesions
- ribosome
- Endoplasmic Reticulum
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Srp68 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane
- response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- signal recognition particle
- focal adhesion
- cytosol
- endoplasmic reticulum
- ribosome
- nucleolus
- signal recognition particle, endoplasmic reticulum targeting
Molecular Function
What the gene product does at the molecular level
- endoplasmic reticulum signal peptide binding
- protein domain specific binding
- RNA binding
- protein binding
- ribosome binding
- 7S RNA binding
- signal recognition particle binding