Ryr1

Enables ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to ATP; negative regulation of transforming growth factor beta receptor signaling pathway; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study myocardial infarction. Biomarker of osteochondrodysplasia and pulmonary hypertension. Human ortholog(s) of this gene implicated in congestive heart failure (multiple); intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ryr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ryr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Ryr1 gene, providing context for its role in the cell.