SRP68 Gene Summary [Human]
This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | SRP68 |
| Official Name | signal recognition particle 68 [Source:HGNC Symbol;Acc:HGNC:11302] |
| Ensembl ID | ENSG00000167881 |
| Bio databases IDs | |
| Aliases | signal recognition particle 68 |
| Synonyms | 2610024I03RIK, LOC103690039, SCN10, signal recognition particle 68 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRP68 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 7S RNA binding
- signal recognition particle binding
- ribosome binding
- protein domain specific binding
- protein binding
- RNA-binding domain of signal recognition particle subunit 68
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- focal adhesions
- ribosome
- Endoplasmic Reticulum
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRP68 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane
- response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- signal recognition particle
- focal adhesion
- cytosol
- endoplasmic reticulum
- ribosome
- nucleolus
- signal recognition particle, endoplasmic reticulum targeting
Molecular Function
What the gene product does at the molecular level
- endoplasmic reticulum signal peptide binding
- protein domain specific binding
- RNA binding
- protein binding
- ribosome binding
- 7S RNA binding
- signal recognition particle binding